| A | B | C | D | E | F | G | H | I | J | K | L | M |
| N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
Name   |
City |
Profession |
Quest |
Members Only |
| Siegfried Erkle | Legends' Guild | Merchant | None. | Yes |
| Santa | Many | Santa | None. | No |
| Saniboch | Brimhaven | Entrance Fee Collector | None. | Yes |
| Sam (merchant) | Wilderness | Merchant | None. | No |
| Simon | Wilderness | Merchant | None. | No |
| Selena | Yanille | Gardener | None. | Yes |
| Sarah (Falador) | Falador | Merchant | None. | Yes |
| Sawmill operator | Varrock | Sawmill operator | None. | No |
| Sergeant Abram | Lumbridge | Guardsmen | None. | No |
| Servant | Evil Bob's Island | Servant | None. | No |
| Sparky | East Ardougne | None | None. | Yes |
| Spider herald | None | Herald | None. | No |
| Spider | None | Spider | None. | No |
| Sentient Lighting (Tuska) | Tuska's back | Anima Islands | None. | No |
| Sheldon | Lumbridge | Merchant | None. | No |
| Sarah (Summer Beach Party) | Lumbridge | Activity hostess | None. | No |
| Saradominist preacher | Lumbridge/Draynor | Warpriest | None. | No |
| Suak | Falador | Supervisor | None. | No |
| Sten | Falador | Smith | None. | No |
| Seiglinde | Keldagrim | Shopkeeper | None. | Yes |
| Squire (Repair NPC) | Void Knights' Outpost | Weapon repair expert | None. | Yes |
| Sir Atcha | Falador | Artefact collector and White Knight Initiate | None. | Yes |
| Sir Pelleas | Camelot | Knight of the Round Table | None | Yes |
| Shop keeper | Most cities | Merchant | None | No |
| Shop assistant | Most cities | Shop assistant | None | No |
| Seravel | Shilo Village | Ticket Vendor | None | Yes |
| Seer | Seers' Village | Sees Things | None | Yes |
| Seaman Lorris | Port Sarim | Sailor | None | No |
| Sabreen | Al Kharid | Nurse | None | No |
| Surgeon General Tafani | Al Kharid | Nurse | None | Yes |
| Sabeil | Al Kharid | Spectator | None | No |
| Sigbert the Adventurer | Agility Dungeon | Adventurer | None | Yes |
| Silk Merchant | Ardougne | Merchant | None | Yes |
| Spice Seller | Ardougne | Merchant | None | Yes |
| Seaman Thresnor | Port Sarim | Sailor | None | No |
| Sergeant | Burthorpe | Soldier Training | None | Yes |
| Scavvo | Varrock | Merchant | None | No |
| Silk trader (Al Kharid) | Al Kharid | Merchant | None | No |
| Sbott | Canifis | Tanner | None | Yes |
| Strange plant | None | None | None | Yes |
| Soldier (Imperial Guard) | Burthorpe | Soldier | None | Yes |
| Sam | Burthorpe | Barmaid | None | Yes |
| Stankers | Seers' Village | Miner | None | Yes |
| Safta Doc | Tai Bwo Wannai Village | Machete smither | None | Yes |
| Shark | None | Shark | None | Yes |
| Solihib | Ape Atoll | Merchant | None | Yes |
| Skullball Boss | Canifis | Manager of the Skullball Course | None | Yes |
| Seddu | Nardah | Armor Seller | None | Yes |
| Sandwich lady | East Ardougne | Vendor | None | Yes |
| Sheepdog | Falador | Sheepdog | None | No |
| Sigurd | Barbarian Village | Canoe master | None | No |
| Smiddi Ryak | Burgh de Rott | Trekker | None | Yes |
| Sune | Keldagrim | Errand Runner | None | Yes |
| Sir Renitee | Falador | Herald | None | Yes |
| Stonemason | Keldagrim | Stonemason | None | Yes |
| Shanomi | Burthorpe | Warrior mage | None | Yes |
| San Fan | Mos Le'Harmless | Pirate | None | Yes |
| Security Guard | Port Sarim | Guard | None | No |
| Sirsal Banker | Lunar Isle | Banker | None | Yes |
| Simon Templeton | Sophanem | Archaeologist | None | Yes |
| Sarble | Tree Gnome Stronghold | Worm and toad keeper | None | Yes |
| Spang | Tree Gnome Stronghold | Food delivery gnome | None | Yes |
| Shanty Claws | Musa Point | Sailor | None | No |
| Sergeant Sambur | None | None | None | Yes |
| Skullball Trainer | Canifis | Trainer of the Skullball Course | None | Yes |
| Sassilik | Jatizso | Citizen | None | Yes |
| Sergeant Damien | None | Drill Sergeant | None | No |
| Stray dog | Varrock | Wanderer | None | No |
| Schoolgirl | Varrock | Student | None | No |
| Schoolboy | Varrock | Student | None | No |
| Sanchez the Cleaner | Wilderness | Cleaner | None | No |
| Snow imp | None | Snow Queen's helper | None | No |
| Stubthumb | Goblin Village | Beacon Tender | None | No |
| Star sprite | None | Star sprite | None | Yes |
| Santa Claus | None | Santa | None | No |
