| A | B | C | D | E | F | G | H | I | J | K | L | M |
| N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
Name   |
City |
Profession |
Quest |
Members Only |
| Supplier | Draynor Village | Supplier | None | Yes |
| Snowy | City of Um | Wildlife | None | Yes |
| Serjeant Cole | None | Serjeant | None | Yes |
| Screech | City of Um | Wildlife | None | Yes |
| Scavvo | Varrock | Merchant | None | No |
| Sergeant Abram | Lumbridge | Guardsmen | None. | No |
| Servant | Evil Bob's Island | Servant | None. | No |
| Sentient Lighting (Tuska) | Tuska's back | Anima Islands | None. | No |
| Spider herald | None | Herald | None. | No |
| Saniboch | Brimhaven | Entrance Fee Collector | None. | Yes |
| Suak | Falador | Supervisor | None. | No |
| Sten | Falador | Smith | None. | No |
| Sheldon | Lumbridge | Merchant | None. | No |
| Spider | None | Spider | None. | No |
| Sarah (Summer Beach Party) | Lumbridge | Activity hostess | None. | No |
| Seiglinde | Keldagrim | Shopkeeper | None. | Yes |
| Squire (Repair NPC) | Void Knights' Outpost | Weapon repair expert | None. | Yes |
| Sam (merchant) | Wilderness | Merchant | None. | No |
| Simon | Wilderness | Merchant | None. | No |
| Saradominist preacher | Lumbridge/Draynor | Warpriest | None. | No |
| Selena | Yanille | Gardener | None. | Yes |
| Sparky | East Ardougne | None | None. | Yes |
| Siegfried Erkle | Legends' Guild | Merchant | None. | Yes |
| Sarah (Falador) | Falador | Merchant | None. | Yes |
| Sir Atcha | Falador | Artefact collector and White Knight Initiate | None. | Yes |
