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Name   |
Location |
Market price |
Quest | Members Only |
| Seiryu's fang | Purchased from Boni. | --- | No | Yes |
| Seismic singularity | Monster drop. | 106.3m gp | No | Yes |
| Seismic singularity shard | Monster drop. | 614.7k gp | No | Yes |
| Seismic wand | Monster drop. | 90.3m gp | No | Yes |
| Seismic wand shard | Monster drop. | 1.2m gp | No | Yes |
| Selected iron | Given to you by the Witch at Draynor Manor in exchange for 5 Iron bars. | --- | Yes | Yes |
| Senliten's mummy | Player made (See Notes Section). | --- | Yes | Yes |
| Senntisten soil | Obtained by excavating Centurion remains during the Archaeology tutorial. | --- | No | No |
| Senntisten teleport | Player Made (See Notes). | 6,199 gp | No | Yes |
| Seren | Received from The Archivist in the Hall of Memories after turning in Aagi. | --- | No | Yes |
| Seren godbow | Can be bought from GE or player-made(See notes) | 696.3m gp | No | Yes |
| Seren insignia | The Heart of Gielinor. | --- | No | Yes |
| Seren shard (dark) | Collected in The Light Within quest inside Morvran's library. | --- | Yes | Yes |
| Seren shard (harmony) | Collected in The Light Within quest inside active Crystal Tree. | --- | Yes | Yes |
| Seren shard (integrity) | Collected in The Light Within quest from clues hidden within Baxtorian's journal. | --- | Yes | Yes |
| Seren shard (prudence) | Collected in The Light Within quest inside Lletya's well. | --- | Yes | Yes |
| Seren shard (wisdom) | Collected in The Light Within quest inside the Hefin Cathedral. | --- | Yes | Yes |
| Seren statuette | Possible loot from Player Kills in PvP or Bounty Hunter Worlds. | 0 gp | No | Yes |
| Seren's symbol | Player made (See Notes Section). | --- | No | Yes |
| Seren's symbol (incomplete) | Bought from any of the clan heralds in Prifddinas e.g. Meilyr herald. | --- | No | Yes |
| Serenic essence | Dropped by Gregorovic. | 229.5k gp | No | Yes |
| Serjeant boots | Bought during the Mobilising Armies mini-game. | --- | No | Yes |
| Serjeant cap | Bought during the Mobilising Armies mini-game. | --- | No | Yes |
| Serjeant gloves | Bought during the Mobilising Armies mini-game. | --- | No | Yes |
| Serjeant skirt | Bought during the Mobilising Armies mini-game. | --- | No | Yes |
| Serjeant top | Bought during the Mobilising Armies mini-game. | --- | No | Yes |
| Serjeant trousers | Bought during the Mobilising Armies mini-game. | --- | No | Yes |
| Serpentine 2h crossbow (level 1) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine 2h crossbow (level 20) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine 2h crossbow (level 40) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine 2h crossbow (level 60) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine 2h crossbow (level 70) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine rapier (level 1) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine rapier (level 20) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine rapier (level 40) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine rapier (level 60) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine rapier (level 70) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine wand (level 1) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine wand (level 20) | This item was a reward from the discontinued Squeal of Fortune. | --- | No | Yes |
| Serpentine wand (level 40) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine wand (level 60) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serpentine wand (level 70) | Won on the Treasure Hunter minigame. | --- | No | Yes |
| Serum 207 (3) | Player made (See Notes Section). | --- | Yes | Yes |
| Serum 208 (3) | Player made (See Notes Section). | --- | Yes | Yes |
| Servant's skull | Grim Reaper's garden. | --- | No | No |
| Severed hoof | Monster drop. | --- | No | Yes |
| Severed leg | Received from General Khazard during The Shadow Sword mini-quest. | --- | No | Yes |
| Sextant | Can be obtained from Murphy after talking to the Observatory professor. | --- | No | Yes |
| Shabby book | Found in the Chaos Room of the Elemental Workshop. | --- | Yes | Yes |
| Shade master kit | The Shade master kit is found from the gold chests (within the Shade Catacombs) in the Shades Of Mort'ton minigame. | --- | No | Yes |
| Shade robe (bottom) | Monster drop. | --- | No | No |
| Shade robe (top) | Monster drop. | --- | No | No |
| Shade skull | Obtained from a gold chest in the Shades' Tomb during Mort'ton Shade Burning (a Gold key is required to open the chest). | --- | No | Yes |
| Shadow | Found in the second chest in the riddle room of Armadyl's Citadel. | --- | Yes | No |
| Shadow animica | Mined from various locations on Erebus. | --- | Yes | Yes |
| Shadow diamond | Dropped by Damis in his lair, west of the Fishing Guild. | --- | Yes | Yes |
| Shadow drake ring | Summer Beach Party of 2016 | --- | No | No |
| Shadow dye | Possible reward from a Reward casket (hard) or Reward casket (elite). | 1,300.0m gp | No | Yes |
| Shadow engrammeter | Player Made (See Notes). | --- | Yes | Yes |
| Shadow engrammeter (depleted) | Obtained from the center of the Vault. | --- | Yes | Yes |
| Shadow fruit | Jadinko Lair offering table, you can buy random fruits in exchange for Jadinko Lair reward points. | --- | No | Yes |
| Shadow glaive | Monster drop; Purchased from the Grand Exchange. | 7.7m gp | No | Yes |
| Shadow glaive shard | Monster drop. | 31.6k gp | No | Yes |
| Shadow jadinko | Result of checking a Shadow jadinko (unchecked); Result of breeding jadinkos at the Ranch Out of Time. | 0 gp | No | Yes |
| Shadow jadinko (unchecked) | Found when hunting Shadow jadinkos. | 1.3m gp | No | Yes |
| Shadow nihil pouch | Player made (See Notes Section). | 111.4k gp | No | Yes |
| Shadow Reef teleport | Purchased from Bryll. | --- | No | Yes |
| Shadow Silk Hood | Monster drop (see Notes section). | 0 gp | No | Yes |
| Shadow sword | Received from General Khazard as a Mini-Quest reward. | --- | No | Yes |
| Shadow vine | Obtained by tracking shadow jadinkos. | --- | No | Yes |
| Shadow ward | Found in the Northern side of the Nodon Front after completing the Shadow Ward puzzle. | --- | Yes | Yes |
| Shadow-infused herb | Harvested from dead Herb patches with either Farmer's Catalyst fragment or Combined Catalyst fragment. | --- | No | Yes |
| Shadowy key | Possible reward from an Ancient casket. | --- | No | Yes |
| Shaikahan bones | Dropped by Karamja jungle monster (Shaikahan). | 67.0k gp | No | Yes |
| Shale tablet | Inside of Zemouregal's fort, during The Curse of Arrav quest. | --- | Yes | Yes |
